Verigat 2.5 | 7*2 pcs Tablet Price | ePharma
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Home Medicines Heart Failure Verigat 2.5mg 7pcs Tablet
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Verigat 2.5mg 7pcs Tablet

Generic: Vericiguat

Type: Tablet

Pack Size: 7pcs

Verigat 2.5 is used for the management of systolic heart failure to reduce mortality and hospitalizations


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Discount Price: ৳ 197.4
MRP: ৳ 210 6% Off

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✅ Description:

Vericiguat is a medication belonging to the class of soluble guanylate cyclase (sGC) stimulators. It is prescribed to reduce the risk of death and hospitalizations in adults with heart failure, a condition where the heart cannot pump blood as efficiently as needed. 

Pack Image of Verigat 2.5 mg Tablet
Verigat 2.5 contains the active ingredient Vericiguat, which works by relaxing the blood vessels, particularly in the lungs, to improve blood flow.

Take Vericiguat exactly as your healthcare provider instructs. While using this medication, you may experience side effects like low blood pressure (hypotension), anemia, dizziness, or light-headedness. These side effects are often temporary and resolve on their own, but if they persist or worsen, consult your doctor.

Before starting Vericiguat, inform your doctor if you have any allergies to medications or food. This medication may cause harm to a fetus, so it is important not to become pregnant while using Vericiguat and for one month after stopping the medication. Effective contraception is advised during treatment. If you or your partner becomes pregnant during therapy, contact your doctor immediately. Breastfeeding is generally not recommended while taking this medication. Its safety and effectiveness in children have not been established.

Safety Advices


Alcohol
UNSAFE

Intake of alcohol should be avoided with Verigat 2.5.


Pregnancy
UNSAFE

Verigat 2.5 should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking Verigat 2.5


Breastfeeding
UNSAFE

Information regarding the use of Verigat 2.5 tablets during breastfeeding is not available. Please consult your doctor.


Driving
CAUTION

Verigat 2.5 may cause dizziness. So, driving vehicles and operating machinery which requires concentration should be avoided.


Kidney
CAUTION

Inform your doctor before using Verigat 2.5 if you have kidney problems or a history of kidney conditions. Your doctor will prescribe only if the benefits outweigh the risks.


Liver
CAUTION

Verigat 2.5 has not been studied in patients with severe hepatic impairment. Inform your doctor before using Verigat 2.5 if you have liver problems or a history of liver conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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✔️ Uses of Verigat 2.5
  • Prevention of Heart failure
✔️ How does Verigat 2.5 work?

Verigat 2.5 turns on a protein (soluble guanylate cyclase) in the body which relaxes the blood vessels and allows more blood to flow through. As a result, the heart can pump better and doesn't have to work as hard.

✔️ Side Effects of Verigat 2.5

Common side effects include:

  • Low blood pressure (hypotension)
  • Low red blood cell count (anemia)
✔️ Quick Suggestions:
  • Monitor your blood pressure regularly since this medicine may cause low blood pressure.
  • Inform your doctor if you are anemic since Vericiguat can cause a decrease in the hemoglobin level.
  • If you feel dizzy while taking this medicine, do not drive a vehicle, or operate any machinery.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking Vericiguat. Barrier methods of contraception, such as condoms should be used during treatment and for 1 month after you stop treatment with Vericiguat.
✔️ Indication of Verigat 2.5

Verigat is used to reduce the risk of cardiovascular death and hospitalization due to heart failure (HF) in adults with symptomatic chronic HF and an ejection fraction of less than 45%, particularly following a hospitalization or need for outpatient intravenous (IV) diuretics.

✔️ Pharmacology

Vericiguat works by stimulating soluble guanylate cyclase (sGC), an enzyme critical to the nitric oxide (NO) signaling pathway. NO binds to sGC, which promotes the production of cyclic guanosine monophosphate (cGMP), a molecule that helps regulate vascular tone, cardiac contractility, and cardiac remodeling. Heart failure is often associated with decreased NO production and reduced sGC activity, leading to impaired heart and vascular function. Vericiguat increases cGMP levels both independently and synergistically with NO, causing smooth muscle relaxation and vasodilation.

✔️ Dosage & Administration of Verigat 2.5
  • Starting Dose: The initial recommended dose of Vericiguat is 2.5 mg once daily with food. The dose can be doubled every 2 weeks to reach the target maintenance dose of 10 mg once daily, based on patient tolerance.
  • For patients unable to swallow tablets: The tablet can be crushed and mixed with water, to be taken immediately before administration, as directed by a physician.
  • Geriatric Patients: No dose adjustment is needed for elderly patients. No significant differences in safety or efficacy have been observed between patients aged 65 years and older compared to younger adults.
  • Hepatic Impairment: No dose adjustment is needed for mild to moderate liver impairment.
  • Renal Impairment: No dose adjustment is required in patients with an estimated glomerular filtration rate (eGFR) ≥15 mL/min/1.73 m² who are not on dialysis. However, Vericiguat has not been studied in patients with eGFR <15 mL/min/1.73 m² or those on dialysis.
  • Pediatric Use: The safety and efficacy of Vericiguat in children have not been established.

Swallow the tablet as a whole with water. Tablets may be crushed and mixed with water for patients who have difficulty swallowing. Use the medicine as prescribed by a registered physician.

✔️ Interaction
  • sGC stimulators: Vericiguat should not be used alongside other soluble guanylate cyclase stimulators.
  • PDE-5 Inhibitors: It is recommended to avoid using Vericiguat with PDE-5 inhibitors as it may cause low blood pressure (hypotension).
  • Food: Vericiguat should be taken with food for maximum bioavailability, which is 93% when taken with a meal.
✔️ Contraindications

Vericiguat is contraindicated in patients who are also taking other soluble guanylate cyclase stimulators.

✔️ Pregnancy & Lactation
  • Pregnancy: Vericiguat is contraindicated during pregnancy due to the risk of harm to the fetus. Females of reproductive potential must use effective contraception during treatment and for one month after stopping treatment.
  • Breastfeeding: There is no information regarding the presence of Vericiguat in human breast milk, its effects on the infant, or its impact on milk production. Due to potential risks to the infant, breastfeeding is not recommended during treatment with Vericiguat.
✔️ Precautions & Warnings

Vericiguat should not be given to pregnant women due to the potential for fetal harm. A pregnancy test should be conducted in females of reproductive age before starting the treatment. Effective contraception should be used during treatment and for one month after discontinuation of the medication.

✔️ Storage Conditions:

Store at a temperature below 30°C, away from light and moisture. Keep the medicine out of the reach of children.

Frequently Asked Questions (FAQ)

There is limited information available about overdoses of Vericiguat. Doses up to 10 mg have been studied, and in some cases, doses of 15 mg were well tolerated in patients with preserved ejection fraction heart failure (left ventricular ejection fraction ≥45%). In the event of an overdose, symptoms like hypotension may occur, and treatment should focus on managing these symptoms. Due to high protein binding, Vericiguat is unlikely to be removed by hemodialysis.

The starting dose is 2.5 mg taken orally once daily with food. The dose may be doubled every two weeks until the target maintenance dose of 10 mg daily is reached.

Vericiguat may not be suitable for individuals with hypotension. Inform your doctor if you have low blood pressure.

Vericiguat may not be appropriate for those with severe anemia. Consult your doctor if you have a history of anemia before starting the medication.

Yes, a healthy diet and regular exercise can improve heart failure symptoms and quality of life.

Vericiguat is prescribed to reduce the risk of death and hospitalization in adults with heart failure.

Yes, dizziness or light-headedness can occur. Rest is recommended, and consult your doctor if the symptoms persist.

No, combining Vericiguat with erectile dysfunction drugs like sildenafil or tadalafil is not recommended as it can interfere with blood pressure regulation.

Vericiguat relaxes blood vessels, making it easier for the heart to pump blood efficiently, reducing the risk of death and hospitalization in heart failure patients.

A heart-healthy diet emphasizes fruits, vegetables, whole grains, low-fat dairy, poultry, fish, and nuts. It limits saturated fats, trans fats, sodium, red meat, sweets, and sugary drinks.

No, Vericiguat may harm a developing baby. It’s essential to avoid pregnancy while on treatment and for at least one month after stopping it. Discuss contraception options with your doctor.

Symptoms include a fast heartbeat, shortness of breath, dizziness, fatigue, coughing, and swelling in the feet or legs.

Vericiguat works by relaxing the pulmonary arteries, making it easier for the heart to pump blood, and reducing the workload on the heart.

Yes, Vericiguat can lower blood pressure, especially after the first dose. Be cautious with activities like driving or operating machinery during the early phase of treatment.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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